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D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis
Panagiotis Paliogiannis1, Arduino Aleksander Mangoni2, Paola Dettori3
1Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Frontiers in Public Health
|September 9, 2020
Summary
Serum D-dimer levels are significantly elevated in patients with severe COVID-19 compared to those with non-severe forms. This finding highlights D-dimer as a key indicator for COVID-19 severity.
Area of Science:
- Medical Research
- Infectious Diseases
- Hematology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to global health challenges.
- Coagulation cascade activation and disseminated intravascular coagulation are linked to adverse outcomes in COVID-19 patients.
Approach:
- A systematic review and meta-analysis was conducted.
- Searched Medline (PubMed), Scopus, and Web of Science for relevant studies.
- Included 13 articles with 1,807 patients to compare D-dimer concentrations.
Key Points:
- Pooled analysis revealed significantly higher serum D-dimer concentrations in severe COVID-19 patients (SMD: 0.91 mg/L).
- Moderate heterogeneity (I² = 46.5%) and no significant publication bias were observed.
- Sensitivity analyses confirmed the robustness of the findings.
Conclusions:
- Serum D-dimer concentrations are significantly elevated in patients with severe COVID-19.
- Elevated D-dimer levels serve as a potential biomarker for COVID-19 severity.
- This meta-analysis reinforces the association between coagulation abnormalities and severe disease manifestations in COVID-19.
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