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Nervous system-immune system interactions: an overview.

A J Dunn1

  • 1Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610.

Journal of Receptor Research
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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The brain and immune system communicate through hormones and neurotransmitters, influencing immune function and stress responses. This neuro-immune axis suggests the brain can monitor immune activity and potentially mitigate stress-related deficits.

Area of Science:

  • Neuroimmunology
  • Psychoneuroimmunology
  • Endocrinology

Background:

  • Behavioral conditioning demonstrates immunosuppression, linking the nervous and immune systems.
  • Brain lesions and stress significantly impact immune responses, indicating neural influence.
  • Physiological and chemical brain changes occur during immune responses.

Purpose of the Study:

  • To explore the intricate links between the nervous and immune systems.
  • To identify key neurochemical mediators involved in neuro-immune interactions.
  • To understand how the brain interprets and responds to immune system challenges.

Main Methods:

  • Review of existing literature on neuro-immune interactions.
  • Analysis of the roles of glucocorticoids, catecholamines, neuropeptides, and pituitary hormones.

Related Experiment Videos

  • Examination of the effects of endogenous opiates on immune cells in vitro and in vivo.

    • Main Results:

    • Glucocorticoids, catecholamines, neuropeptides, pituitary hormones, and immune cell polypeptides mediate neuro-immune communication.
    • Glucocorticoid effects are not solely immunosuppressive and do not fully explain stress impacts.
    • In vitro, opiates enhance lymphocyte and natural killer (NK) cell activity, but in vivo, they inhibit immune responses and tumor rejection.

    Conclusions:

    • Immune system challenges are perceived as stressors by the brain, evidenced by increased glucocorticoids and activated catecholaminergic cells.
    • The brain may possess mechanisms to monitor ongoing immune responses.
    • Thymosins, produced by the thymus, show potential in counteracting stress-induced immune deficits.