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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Related Experiment Video

Updated: Dec 9, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Capturing complex epigenetic phenomena through human multicellular systems.

Dilara Sen¹, Albert J Keung¹

¹North Carolina State University, Raleigh, NC 27606.

Current Opinion in Biomedical Engineering

|September 9, 2020

Summary

This summary is machine-generated.

Multicellular systems offer a natural way to model complex epigenetic phenomena, mirroring in vivo conditions. These systems can generate diverse cellular states, aiding research into development and disease.

Keywords:

3D aging development epigenetics multicellular organoids

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Last Updated: Dec 9, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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Published on: April 5, 2018

Reusable Single Cell for Iterative Epigenomic Analyses

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Published on: February 11, 2022

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

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Published on: April 21, 2023

Area of Science:

Cellular and Molecular Biology
Epigenetics and Disease Modeling

Background:

Epigenetic states are crucial for biological phenotypes in development and disease.
Accurate cellular models require capturing epigenetic complexity and chromatin biochemistry.
DNA and histone modifications are key components of epigenetic regulation.

Purpose of the Study:

To highlight the utility of multicellular systems for modeling epigenetic phenomena.
To discuss how multicellular systems mimic in vivo environments.
To explore the potential of multicellular systems in generating multiple cellular states.

Main Methods:

Review of recent research on multicellular systems for epigenetic modeling.
Analysis of how multicellular systems capture in vivo conditions.
Examination of intrinsic capabilities of multicellular systems to model diverse cellular states.

Main Results:

Multicellular systems naturally capture complex epigenetic phenomena.
These systems closely match in vivo environments.
Multicellular systems can generate and model multiple distinct cellular states within a single system.

Conclusions:

Multicellular systems provide a powerful approach for studying epigenetics.
Challenges and limitations in current multicellular systems are discussed.
Molecular interventions can enhance the utility of these epigenetic models.