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Striatal Oscillations in Parkinsonian Non-Human Primates.

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  • 1Yerkes National Primate Research Center, Emory University Atlanta, GA, United States; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.

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Parkinson's disease (PD) involves abnormal brain oscillations. This study found pathological alpha and low-beta band oscillations in the striatum of non-human primates with PD, which decreased with levodopa treatment.

Keywords:
Parkinson’s diseasedopaminelocal field potentialsnon-human primatesstriatal projection neurons

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Area of Science:

  • Neuroscience
  • Movement Disorders
  • Parkinson's Disease Research

Background:

  • Dopamine depletion in Parkinson's disease (PD) is linked to aberrant brain network oscillations.
  • The specific oscillatory patterns within the striatum in PD remain inadequately understood.

Purpose of the Study:

  • To investigate the oscillatory activity in the striatum of non-human primates (NHPs) exhibiting chronic parkinsonism.
  • To determine if striatal oscillations correlate with abnormal activity in the cortico-basal ganglia network in PD models.
  • To assess the effect of levodopa treatment on these striatal oscillations.

Main Methods:

  • Analysis of local field potentials (LFPs) in untreated and MPTP-induced parkinsonian NHPs.
  • Examination of oscillatory activity in the alpha (8-13 Hz) and low-beta (13-20 Hz) frequency bands.
  • Assessment of coherence between striatal, cortical, and pallidal oscillations.
  • Evaluation of LFP changes following acute levodopa administration.

Main Results:

  • Abnormal alpha and low-beta frequency oscillations were identified in the striatum of parkinsonian NHPs.
  • Striatal oscillations were highly coherent with oscillations in the motor cortex and globus pallidus.
  • Treatment with levodopa led to a reduction in these pathological 8-20 Hz oscillations in the striatum.

Conclusions:

  • Pathological alpha and low-beta band oscillations are present in the striatum of the NHP model of Parkinson's disease.
  • These striatal oscillations are synchronized with abnormal activity in the broader cortico-basal ganglia network.
  • The findings suggest that targeting these pathological oscillations may be a therapeutic strategy for PD.