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Selenium deficiency is linearly associated with hypoglycemia in healthy adults
Yue Wang1, Eddy Rijntjes2, Qian Wu3
1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Redox Biology
|September 9, 2020
Summary
Low selenium (Se) intake is linked to both high and low blood glucose levels in humans. Adequate selenium is crucial for maintaining glucose homeostasis and may impact severe disease outcomes.
Area of Science:
- Biochemistry
- Human Physiology
- Nutritional Science
Background:
- Selenium (Se) is essential for selenoprotein synthesis, impacting antioxidant defense and redox signaling.
- High Se intake is linked to hyperglycemia and insulin resistance.
- The impact of low Se intake on glucose metabolism is not well understood.
Purpose of the Study:
- To investigate the relationship between selenium status and glucose levels in humans.
- To explore the role of selenium in glucose homeostasis and carbohydrate metabolism.
Main Methods:
- Cross-sectional analysis of 5686 healthy adults from two Chinese counties with varying Se intakes.
- Linear regression analysis correlating serum Se concentrations with fasted glucose levels, adjusting for BMI, age, thyroid status, insulin, and sex.
Main Results:
- Serum Se showed a strong positive correlation with glucose in Se-deficient individuals.
- No significant Se-glucose relationship was observed in the non-deficient population.
- Hypoglycemia (serum glucose < 2.8 mM) was significantly more prevalent in the Se-deficient group (19.2%) compared to the moderately supplied group (1.4%).
Conclusions:
- Adequate selenium supply is vital for maintaining human glucose homeostasis.
- Selenium deficiency is associated with an increased risk of both hyperglycemia and hypoglycemia.
- These findings highlight the importance of Se status in managing severe conditions like sepsis and COVID-19.
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