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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Related Experiment Video

Updated: Dec 9, 2025

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Latest Development in Multiple Myeloma.

Yoichi Imai1

  • 1Department of Hematology/Oncology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 113-8654, Japan.

Cancers
|September 10, 2020
PubMed
Summary

This special issue presents 12 articles on multiple myeloma (MM) research, including original studies and reviews. It covers the latest advancements and insights into this complex blood cancer.

Keywords:
ASCTAXLCAR T-cell therapyKRASMRDchronic painhepatitis B virusimmunotherapylong-lived plasma cellsmiRNAsmultiple myelomaproteasome inhibitor

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Area of Science:

  • Hematology
  • Oncology
  • Biomedical Research

Background:

  • Multiple Myeloma (MM) is a complex hematologic malignancy.
  • Recent advancements necessitate a consolidated overview of current research.

Discussion:

  • The Special Issue compiles 12 articles, featuring 2 original research papers and 10 comprehensive reviews.
  • These articles address critical aspects of multiple myeloma.
  • The collection offers insights into the latest developments in MM research.

Key Insights:

  • The issue highlights cutting-edge findings and therapeutic strategies in multiple myeloma.
  • It provides a valuable resource for understanding the current landscape of MM research.
  • Expert contributions offer diverse perspectives on MM pathogenesis and treatment.

Outlook:

  • Future research directions in multiple myeloma are explored.
  • The compendium aims to guide ongoing and future investigations in the field.
  • This collection serves as a foundation for advancing multiple myeloma care.