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Related Experiment Video

Updated: Dec 9, 2025

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

Macroporous surface modified microparticles.

Owen R Davies¹, Maria Marlow², Snow Stolnik¹

¹School of Pharmacy, University of Nottingham, University Park, Nottingham, UKNG7 2RD. snjezana.stolnik@nottingham.ac.uk.

|September 10, 2020

Summary

Researchers developed new porous polymeric microparticles capable of loading DNA. These functionalized microparticles show promise for biologic drug delivery and tissue engineering applications.

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Last Updated: Dec 9, 2025

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

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Published on: May 16, 2022

Harvesting Murine Alveolar Macrophages and Evaluating Cellular Activation Induced by Polyanhydride Nanoparticles

Harvesting Murine Alveolar Macrophages and Evaluating Cellular Activation Induced by Polyanhydride Nanoparticles

Published on: June 8, 2012

Area of Science:

Polymer Science
Biomaterials Engineering
Drug Delivery Systems

Background:

Developing effective delivery systems for biologics is crucial for advanced therapeutics.
Tissue engineering requires biocompatible scaffolds that can support cell growth and function.

Purpose of the Study:

To prepare novel macroporous and surface-functionalized polymeric microparticles.
To evaluate the capacity of these microparticles for surface DNA loading.
To explore their potential applications in drug delivery and tissue engineering.

Main Methods:

Utilized a modified emulsion technique for microparticle synthesis.
Characterized the macroporous structure and surface functionality of the prepared particles.
Assessed the DNA loading efficiency onto the microparticle surfaces.

Main Results:

Successfully synthesized macroporous polymeric microparticles with functionalized surfaces.
Demonstrated efficient surface loading of DNA onto the microparticles.
The microparticles exhibited characteristics suitable for biologic drug delivery and tissue engineering.

Conclusions:

The developed microparticles offer a promising platform for advanced biologic drug delivery.
These functionalized microparticles represent a potential advancement in tissue engineering scaffolds.
The modified emulsion technique provides a viable route for creating specialized microparticle systems.