Related Experiment Video
Updated: Dec 9, 2025
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
26.3K
Report from an effort to prevent type 2 diabetes development in primary care
Margareta I Hellgren1, Per-Anders Jansson2, Ulf Lindblad3
1Department of Public Health and Community Medicine/Primary Health Care, The Sahlgrenska Academy at the University of Gothenburg, Sweden; The Skaraborg Institute, Skövde, Sweden.
Primary Care Diabetes
|September 10, 2020
Summary
A lifestyle intervention for prediabetes improved weight and blood pressure long-term. However, it did not significantly alter insulin resistance or the incidence of type 2 diabetes over five years.
Area of Science:
- Clinical Medicine
- Metabolic Health
- Preventive Cardiology
Background:
- Prediabetes increases type 2 diabetes risk.
- A previous trial showed lifestyle intervention (LI) reduced insulin resistance compared to usual care (CAU).
- Extended follow-up assessed long-term metabolic effects of LI.
Purpose of the Study:
- To evaluate sustained effects of a physical activity-focused lifestyle intervention (LI) on metabolic variables in prediabetes.
- To determine if benefits on insulin resistance and type 2 diabetes incidence persist five years post-intervention.
Main Methods:
- Extended follow-up of a randomized clinical trial comparing LI to CAU.
- Data collection included oral glucose tolerance tests, anthropometrics, blood pressure, blood samples, and lifestyle questionnaires.
- Analysis included 74 participants from the original cohort.
Main Results:
- The LI group demonstrated sustained reductions in diastolic blood pressure and body weight compared to baseline.
- Weight loss was significantly greater in the LI group versus the CAU group.
- No significant differences were observed in insulin resistance markers or type 2 diabetes incidence between groups at extended follow-up.
Conclusions:
- A physical activity intervention can lead to sustainable weight loss in prediabetes patients.
- The intervention did not significantly impact type 2 diabetes incidence or insulin resistance levels long-term.
- Lifestyle interventions focusing on physical activity may be beneficial for weight management in primary care settings for individuals with prediabetes.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
4.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.1K
01:15Diabetes: Management and Pharmacotherapy
763
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
763
01:30Preventive Healthcare Services
1.7K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.7K
01:36Carbohydrate Metabolism
13.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.2K
01:22Diabetes Mellitus: Overview and Type I Subtype
4.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.6K
01:15Diabetes: Symptoms, Diagnosis, and Complications
1.8K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.8K