Related Experiment Video
Updated: Dec 9, 2025
07:03
Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
2.4K
Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential
Ashley G Zhao1, Kiran Shah1,2, Brett Cromer1
1Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, John St., Hawthorn VIC 3122, Australia.
Stem Cells International
|September 10, 2020
Summary
Extracellular vesicles (EVs), nanoparticles from cells, deliver biomolecules and have therapeutic potential. Mesenchymal stem cell-derived EVs offer cell-free therapy advantages for regenerative medicine.
Area of Science:
- Cell biology
- Nanomedicine
- Regenerative medicine
Background:
- Extracellular vesicles (EVs) are nanoparticles involved in intercellular communication, impacting homeostasis and disease.
- EVs possess significant diagnostic and therapeutic potential across various scientific fields.
- Mesenchymal stem cells (MSCs) are recognized for their therapeutic applications and prolific EV production.
Purpose of the Study:
- To review the biogenesis of EVs, including exosomes and microvesicles.
- To focus on mesenchymal stem cell-derived EVs (MSC-EVs).
- To highlight the therapeutic potential and applications of MSC-EVs in regenerative medicine and tissue engineering.
Main Methods:
- Review of existing literature on EV biogenesis.
- Analysis of studies investigating MSC-derived EVs.
- Synthesis of information on MSC-EV applications in regenerative medicine and tissue engineering.
Main Results:
- EVs function as crucial intercellular shuttles for biomolecules.
- MSC-EVs are explored as cell-free therapeutic alternatives to MSCs.
- MSC-EVs offer advantages like lower immunogenicity and fewer safety concerns compared to cells.
Conclusions:
- MSC-derived EVs hold substantial promise for therapeutic applications.
- MSC-EVs are key candidates for advancements in regenerative medicine and tissue engineering.
- Further research into MSC-EVs can unlock their full clinical potential.
Related Concept Videos
01:19Mesenchymal Stem Cells
5.3K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.3K
01:36Overview of Exosomes
3.3K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.3K