Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Bone Remodeling01:40

Bone Remodeling

39.9K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.9K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.2K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

138
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
138
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.6K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Recommendation for FLS Certification for General Surgery Residents By the End of the PGY-2 Year.

Annals of surgery·2026
Same author

Erratum to American Society for Gastrointestinal Endoscopy-European Society of Gastrointestinal Endoscopy guideline on primary endoscopic bariatric and metabolic therapies for adults with obesity, Gastrointestinal Endoscopy Volume 99, Issue 6, June 2024, Pages 867-885.e64.

Gastrointestinal endoscopy·2025
Same author

Correction: American Society for Gastrointestinal Endoscopy-European Society of Gastrointestinal Endoscopy guideline on primary endoscopic bariatric and metabolic therapies for adults with obesity.

Endoscopy·2025
Same author

EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults.

Surgical endoscopy·2024
Same author

American Society for Gastrointestinal Endoscopy-European Society of Gastrointestinal Endoscopy guideline on primary endoscopic bariatric and metabolic therapies for adults with obesity.

Gastrointestinal endoscopy·2024
Same author

American Society for Gastrointestinal Endoscopy-European Society of Gastrointestinal Endoscopy guideline on primary endoscopic bariatric and metabolic therapies for adults with obesity.

Endoscopy·2024
Same journal

Efficacy and safety of transoral incisionless fundoplication in non-obese and obese adults: a population-based cohort study from the United States.

Surgical endoscopy·2026
Same journal

Minimally invasive versus open surgery for adhesive small bowel obstruction: a systematic review and meta-analysis.

Surgical endoscopy·2026
Same journal

Enhanced view/extended totally extraperitoneal plasty (eTEP) Rives-Stoppa repair versus open Rives-Stoppa repair: a single-center retrospective propensity score-matched cohort study.

Surgical endoscopy·2026
Same journal

Robotic-assisted endoscopic submucosal dissection: a scoping review of preclinical and early clinical evidence.

Surgical endoscopy·2026
Same journal

Conversion of endoscopic sleeve gastroplasty to bariatric surgery.

Surgical endoscopy·2026
Same journal

Artificial intelligence and chatbots in general surgery: a survey among surgeons in Germany, Austria and Switzerland.

Surgical endoscopy·2026
See all related articles

Related Experiment Video

Updated: Dec 9, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.0K

Bone mineral density changes after bariatric surgery.

Kelly Ieong1, Jessica Ardila-Gatas2, Jie Yang3

  • 1Division of Bariatric, Foregut, and Advanced Gastrointestinal Surgery, Department of Surgery, Health Sciences Center, T19-053, Stony Brook Medicine, Stony Brook, NY, 11794-8191, USA. Kelly.ieong@stonybrookmedicine.edu.

Surgical Endoscopy
|September 10, 2020
PubMed
Summary
This summary is machine-generated.

Bariatric surgery, including Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), leads to decreased bone mineral density (BMD). Monitoring vitamin D and calcium levels is crucial post-surgery to mitigate bone loss risks.

Keywords:
BariatricBone mineral densityDEXAGastric bypassSleeve gastrectomy

More Related Videos

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
10:39

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology

Published on: December 7, 2011

15.4K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.1K

Related Experiment Videos

Last Updated: Dec 9, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.0K
Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
10:39

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology

Published on: December 7, 2011

15.4K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.1K

Area of Science:

  • Endocrinology
  • Orthopedics
  • Bariatric Surgery

Background:

  • Bariatric surgery offers health benefits but can decrease bone mass.
  • Roux-en-Y gastric bypass (RYGB) is linked to bone loss and fractures.
  • Data on sleeve gastrectomy (SG) and its effect on bone mineral density (BMD) is limited.

Purpose of the Study:

  • To compare bone mineral density (BMD) changes after RYGB versus SG.
  • To investigate the impact of vitamin D and calcium levels on BMD post-SG.

Main Methods:

  • Retrospective chart review of patients undergoing RYGB or SG (2014-2016).
  • Included patients with pre- and post-operative bone densitometry within 2 years.
  • Analyzed serum 25-hydroxy vitamin D and calcium levels alongside BMD and T-score changes.

Main Results:

  • Both RYGB and SG groups showed decreased BMD post-surgery.
  • Serum 25-hydroxy vitamin D decrease correlated with lumbar spine BMD and T-score reduction.
  • Serum calcium decrease correlated with femoral neck BMD reduction.

Conclusions:

  • All bariatric surgery patients experienced decreased BMD, irrespective of surgery type.
  • Decreased vitamin D and calcium levels are associated with reduced BMD, even with supplementation.
  • Close monitoring and management of vitamin D and calcium are essential for bariatric patients.