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Updated: Dec 9, 2025
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Two simple and rapid methods based on maximum diameter accurately estimate large lesion volumes in acute stroke
Anna Kufner1,2, Jonas Stief3, Bob Siegerink1,2
1Department of Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin, Berlin, Germany.
Background:
We compared two simple and rapid diameter-based methods (ABC/2, od-value) in terms of their accuracy in predicting lesion volume >70 ml and >100 ml.
Methods:
In 238 DWI images of ischemic stroke patients from the AXIS2 trial, maximum lesion diameter and corresponding maximum orthogonal diameter were measured. Estimation of infarct volume based on od-value and ABC/2 calculation was compared to volumetric assessments.
Results:
Accuracy of od-value and ABC/2 was similar for >70 ml (92.0 vs. 87.4) and >100 ml (92.9 vs. 93.3). ABC/2 overestimated lesion volume by 29.9%, resulting in a lower specificity.
Conclusions:
Od-value is a robust tool for patient selection in trials.
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