Two simple and rapid methods based on maximum diameter accurately estimate large lesion volumes in acute stroke
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Updated: Dec 9, 2025
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Anna Kufner1,2, Jonas Stief3, Bob Siegerink1,2
1Department of Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin, Berlin, Germany.
Background:
We compared two simple and rapid diameter-based methods (ABC/2, od-value) in terms of their accuracy in predicting lesion volume >70 ml and >100 ml.
Methods:
In 238 DWI images of ischemic stroke patients from the AXIS2 trial, maximum lesion diameter and corresponding maximum orthogonal diameter were measured. Estimation of infarct volume based on od-value and ABC/2 calculation was compared to volumetric assessments.
Results:
Accuracy of od-value and ABC/2 was similar for >70 ml (92.0 vs. 87.4) and >100 ml (92.9 vs. 93.3). ABC/2 overestimated lesion volume by 29.9%, resulting in a lower specificity.
Conclusions:
Od-value is a robust tool for patient selection in trials.
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