Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...

Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of pilocarpine effects on sweat proteome.

Journal of proteomics·2026

Same author

Eccentric exercise training in multiple sclerosis management -a scoping review.

Multiple sclerosis and related disorders·2026

Same author

Indirect calorimetry in canopy mode in healthy subjects: performances of the Q-NRG device compared to the Deltatrac II.

Acta gastro-enterologica Belgica·2025

Same author

Evaluation of intensive rehabilitation under continuous suprascapular nerve blockade for the treatment of refractory adhesive shoulder capsulitis. Case series.

Revista espanola de anestesiologia y reanimacion·2022

Same author

[Neuromusculoskeletal disorders related to musical playing - a review of the literature].

Revue medicale de Liege·2022

Same author

[Psychological and cognitive interventions in end-of-life support of patients with amyotrophic lateral sclerosis. A review.]

Revue medicale de Liege·2022

Search research articles

Related Experiment Video

Updated: Dec 9, 2025

Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Published on: April 21, 2023

[Diastematomyelia discovered in adulthood].

F Grailet¹, B Maillard², M Tomasella²

¹Faculté de Médecine, ULiège, Belgique.

Revue Medicale De Liege

|September 10, 2020

Summary

This case study highlights diastematomyelia, a rare adult congenital anomaly causing lumbar pain. Early diagnosis and proper management are crucial to prevent neurological deterioration.

Keywords:

Spinal dysraphism Split cord malformation Diastematomyelia type 1

More Related Videos

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Published on: May 17, 2024

Related Experiment Videos

Last Updated: Dec 9, 2025

Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Published on: April 21, 2023

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Published on: May 17, 2024

Area of Science:

Neurology
Medical Imaging
Congenital Abnormalities

Background:

Diastematomyelia is a rare congenital spinal malformation, typically diagnosed in utero.
Adult presentation of diastematomyelia is uncommon and often discovered incidentally.
Recurrent lumbar pain and cruralgia can be presenting symptoms in adults.

Observation:

A 35-year-old woman presented with chronic lumbar pain and left-sided leg pain (cruralgia).
Imaging revealed a congenital anomaly, later diagnosed as diastematomyelia.
This diagnosis was made fortuitously through a scanner (CT scan).

Findings:

Diastematomyelia, a split spinal cord malformation, is rare in adulthood.
Associated malformations can suggest the presence of diastematomyelia.
The case underscores the importance of thorough iconographic assessment.

Implications:

Management strategies for adult diastematomyelia remain controversial.
Inadequate management can result in significant and disabling neurological deficits.
This case emphasizes the need for increased awareness and diagnostic vigilance for spinal malformations in adults presenting with chronic pain.