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Late-onset schizophrenia: an overview.

M J Harris1, D V Jeste

  • 1Psychiatry Service, San Diego Veterans Administration Medical Center, CA 92161.

Schizophrenia Bulletin
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Late-onset schizophrenia, occurring after age 40, is a valid diagnosis despite methodological challenges. This condition presents with specific symptoms and characteristics, warranting further research.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Gerontology

Background:

  • The onset of schizophrenia after age 40 has been a subject of debate within the medical community.
  • Existing research on late-onset schizophrenia is extensive but often suffers from methodological limitations, particularly in accurately determining symptom onset.

Purpose of the Study:

  • To review and synthesize findings from over 30 publications on schizophrenia with onset after age 40.
  • To evaluate the evidence supporting late-onset schizophrenia as a distinct clinical entity.
  • To identify characteristic features and epidemiological patterns of late-onset schizophrenia.

Main Methods:

  • Systematic review of more than 30 published studies focusing on schizophrenia onset after age 40.
  • Analysis of study methodologies to identify common shortcomings, especially concerning the precise dating of schizophrenia onset.

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  • Synthesis of clinical, demographic, and familial data associated with late-onset schizophrenia.

    • Main Results:

    • A significant proportion of individuals are diagnosed with schizophrenia for the first time after age 40.
    • Late-onset schizophrenia is associated with paranoid symptoms, a higher prevalence in females, hearing and vision impairments, premorbid schizoid or paranoid personality traits, and chronicity.
    • Family studies indicate a higher familial prevalence of schizophrenia in late-onset cases compared to the general population, but lower than in early-onset schizophrenia.

    Conclusions:

    • Late-onset schizophrenia is considered a valid clinical entity or a group of related entities.
    • Further research into the course, biological markers, neuropsychological profile, and treatment response of late-onset schizophrenia is essential.