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Pregnancy issues in Takayasu arteritis.

Cloe Comarmond1, David Saadoun1, Jacky Nizard2

  • 1Department of Internal Medicine and Clinical Immunology, Centre de Référence des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Maladies Auto-Inflammatoires, F-75013, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière.

Seminars in Arthritis and Rheumatism
|September 10, 2020
PubMed
Summary
This summary is machine-generated.

Pregnancy in Takayasu arteritis (TAK) patients is high-risk. Active disease significantly worsens pregnancy outcomes and increases maternal cardiovascular complications, necessitating expert collaboration for better results.

Keywords:
PregnancyTakayasu arteritis

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Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Obstetrics

Background:

  • Takayasu arteritis (TAK) is a rare, chronic inflammatory disease affecting large arteries, primarily the aorta.
  • TAK predominantly impacts young women, presenting unique challenges for managing pregnancy.
  • Pregnancy in TAK patients requires careful consideration due to potential maternal and fetal risks.

Purpose of the Study:

  • To evaluate pregnancy outcomes in women with Takayasu arteritis.
  • To determine the impact of TAK disease activity and onset on pregnancy complications.
  • To assess the effect of pregnancy on the long-term prognosis of TAK.

Main Methods:

  • A comprehensive literature review was conducted.
  • Data from 505 pregnancies in 373 TAK patients were analyzed.
  • Outcomes were assessed in relation to disease activity and clinical presentation.

Main Results:

  • Active Takayasu arteritis is independently linked to adverse pregnancy outcomes.
  • Over 5% of pregnant TAK patients experienced life-threatening cardiovascular complications.
  • Effective control of TAK and hypertension before and during pregnancy is crucial.

Conclusions:

  • Pregnancies in women with Takayasu arteritis are considered high-risk.
  • Close collaboration between rheumatologists, cardiologists, and obstetricians is essential.
  • Optimizing disease control improves maternal and fetal outcomes in TAK pregnancies.