Related Experiment Video
Updated: Dec 9, 2025
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
15.1K
Occupational and Environmental Carcinogenesis
Caterina Ledda1, Venerando Rapisarda1
1Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Via Santa Sofia, 87-95123 Catania, Italy.
Cancers
|September 11, 2020
Summary
Occupational carcinogens significantly contribute to national and global disease burdens. Identifying and mitigating these workplace cancer risks is crucial for public health.
Area of Science:
- Occupational health
- Environmental toxicology
- Cancer epidemiology
Background:
- Workplace exposure to carcinogens presents a substantial public health challenge.
- Quantifying the disease burden from occupational carcinogens is essential for targeted interventions.
Discussion:
- The impact of occupational carcinogens necessitates robust regulatory frameworks.
- Understanding exposure pathways is key to reducing cancer incidence in workers.
Key Insights:
- Occupational carcinogens are a major driver of preventable diseases globally.
- Effective risk management strategies can alleviate the societal cost of occupational cancers.
Outlook:
- Future research should focus on novel methods for carcinogen detection and control.
- Policy development must prioritize worker safety and long-term health outcomes.
Related Concept Videos
01:25Mutagenicity and Carcinogenicity
1.7K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.7K
02:59Cancer Prevention
7.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.5K
01:36Types of Toxins
3.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.0K
01:30Skin Cancer
5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
01:28Criteria for Causality: Bradford Hill Criteria - II
1.0K
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.0K
01:39Mutations
93.3K
Overview
93.3K