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Related Experiment Video

Updated: Dec 9, 2025

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
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Organs-on-chips: into the next decade.

Lucie A Low1, Christine Mummery2,3, Brian R Berridge4

  • 1National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. lucie.low@nih.gov.

Nature Reviews. Drug Discovery
|September 11, 2020
PubMed
Summary
This summary is machine-generated.

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Organs-on-chips (OoCs) offer advanced insights into human organ function and disease, promising to improve drug discovery and development. These microphysiological systems may soon supplement or replace traditional preclinical methods.

Area of Science:

  • Biomedical Engineering
  • Drug Discovery
  • Translational Medicine

Background:

  • Organs-on-chips (OoCs), also known as microphysiological systems or tissue chips, are gaining significant attention.
  • They hold potential for understanding human organ function, disease, and predicting drug efficacy and safety.

Purpose of the Study:

  • To review the current state of organs-on-chips technology.
  • To discuss applications, challenges, and future directions in the field.

Main Methods:

  • Review of recent advances in OoC technology.
  • Analysis of current applications and limitations.
  • Identification of interdisciplinary needs for future development.

Main Results:

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  • OoCs show promise in drug discovery and preclinical testing.
  • Significant progress has been made in OoC sophistication and physiological relevance.
  • New challenges and opportunities have emerged in the field.

Conclusions:

  • OoCs are poised to become valuable tools in drug development, potentially replacing traditional methods.
  • Continued advancements require interdisciplinary collaboration.
  • The next decade holds significant opportunities for OoC technology in fundamental and translational research.