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The main obstacle to a malaria vaccine: the malaria parasite
1Laboratory of Parasitic Diseases, NIAID, Bethesda, MD 20892.
Vaccine
|April 1, 1988
Abstract:
The challenge to development of a malaria vaccine will be the variability of the sequences of target antigens. We discuss the variability in the T cell epitopes on the circumsporozoite protein of Plasmodium falciparum and the rapid selection of mutants after immunization with a protein from the asexual erythrocytic stage of P. knowlesi.