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A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
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A mock circulation loop to test extracorporeal CO2 elimination setups.

Leonie S Schwärzel1, Anna M Jungmann1, Nicole Schmoll1

  • 1Department of Internal Medicine V - Pneumology and Intensive Care Medicine, University Hospital of Saarland, Kirrbergerstr. 1, 66421, Homburg, Germany.

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This study introduces a novel in-vitro extracorporeal carbon dioxide removal (ECCO2R) model, simplifying research without animal use. The model effectively investigates factors like hemoglobin concentration and air-based systems for improved CO2 clearance.

Keywords:
ARDSCOPDECCO2RECMOMock circulation

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Area of Science:

  • Biomedical Engineering
  • Respiratory Physiology
  • Medical Device Development

Background:

  • Extracorporeal carbon dioxide removal (ECCO2R) is a developing therapy for hypercapnic respiratory failure.
  • Current research is limited, often requiring animal models.
  • A novel in-vitro mock circuit is presented to facilitate ECCO2R research.

Purpose of the Study:

  • To develop and validate a cost-effective in-vitro ECCO2R model.
  • To investigate the impact of hemoglobin concentration on CO2 removal.
  • To evaluate air-driven and low-flow ECCO2R systems.

Main Methods:

  • Development of a mock ECCO2R circuit using porcine blood or human red blood cells.
  • Experimental testing of three ECCO2R scenarios: hemoglobin influence, air-based sweep gas, and low-flow recirculation.
  • Measurement of CO2 removal rates under varying conditions.

Main Results:

  • The mock circuit achieved CO2 removal rates comparable to existing studies.
  • Hemoglobin concentration significantly influenced CO2 removal efficiency.
  • Air-driven ECCO2R showed only slightly reduced CO2 removal compared to oxygen.
  • Low-flow recirculation with acidification enhanced CO2 clearance.

Conclusions:

  • A simple, cost-effective in-vitro ECCO2R model offers an alternative to animal testing.
  • This model allows for easier manipulation of parameters like hemoglobin levels.
  • The findings support further development of advanced ECCO2R techniques.