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Serotonin in nasal secretion.

P Tønnesen1, I Hindberg

  • 1Pulmonary Dept., Gentofte Hospital, Copenhagen, Denmark.

Allergy
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Serotonin was detected in most nasal secretions from healthy individuals and rhinitis patients. Further research is needed to understand serotonin

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Area of Science:

  • Otorhinolaryngology
  • Neuroscience
  • Biochemistry

Background:

  • Serotonin plays a role in various physiological processes.
  • Its presence and function in nasal secretions are not well understood.

Purpose of the Study:

  • To investigate the concentration and presence of serotonin in nasal secretions.
  • To compare serotonin levels in normal subjects and patients with rhinitis.

Main Methods:

  • Collected histamine- and methacholine-induced nasal secretions from 33 normal subjects.
  • Collected allergen-induced nasal secretions from 7 rhinitis patients.
  • Determined serotonin concentration using radioenzymatic assay.

Main Results:

  • Serotonin was found in 66% of pure, blown nasal secretions.

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  • Median serotonin concentrations were 6.3 nmol/l (histamine) and 2.3 nmol/l (methacholine) in normal subjects.
  • Serotonin levels in rhinitis patients (median 10.4 nmol/l) did not differ significantly from normal subjects.

    • Conclusions:

    • Serotonin is present in human nasal secretions.
    • Further investigation into the role of serotonin in nasal hypersecretion is warranted.