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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Related Experiment Video

Updated: Dec 9, 2025

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
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Epitranscriptomics in Normal and Malignant Hematopoiesis.

Crescenzio Francesco Minervini1, Elisa Parciante1, Luciana Impera1

  • 1Department of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.

International Journal of Molecular Sciences
|September 12, 2020
PubMed
Summary
This summary is machine-generated.

Epitranscriptomics, the study of RNA modifications, offers new insights into blood cell development (hematopoiesis) and its role in malignant conditions. This research explores epitranscriptomic roles in normal and cancerous hematopoiesis for therapeutic potential.

Keywords:
epitranscriptomicshematological malignancieshematopoiesis

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Area of Science:

  • Biochemistry and Molecular Biology
  • Genetics and Genomics
  • Cell Biology

Background:

  • Epitranscriptomics investigates RNA modifications, adding a regulatory layer to genetic information.
  • These modifications influence crucial cellular processes like the cell cycle and differentiation.
  • Hematopoiesis, the process of blood cell formation, is tightly regulated but can be disrupted in malignant conditions.

Purpose of the Study:

  • To review the role of epitranscriptomic events in both normal and malignant hematopoiesis.
  • To explore the pathophysiological and therapeutic implications of epitranscriptomics in blood disorders.
  • To provide an evolutionary perspective on epitranscriptomic mechanisms in hematopoiesis.

Main Methods:

  • Literature review focusing on epitranscriptomics and hematopoiesis.
  • Analysis of existing studies on RNA modifications in blood cell development.
  • Synthesis of information regarding the link between epitranscriptomics and hematopoietic malignancies.

Main Results:

  • Epitranscriptomic modifications are implicated in regulating normal hematopoiesis.
  • Aberrant epitranscriptomic events contribute to the development of malignant hematopoiesis.
  • Understanding these mechanisms opens new avenues for diagnostics and therapeutics.

Conclusions:

  • Epitranscriptomics represents a critical regulatory layer in hematopoiesis.
  • Targeting epitranscriptomic pathways holds promise for treating hematologic malignancies.
  • Further research into the evolutionary aspects of epitranscriptomics may yield novel insights.