Related Experiment Video
Updated: Aug 11, 2026
A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
Novel and conventional embryo parameters as input data for artificial neural networks: an artificial intelligence
Lorena Bori1, Elena Paya2, Lucia Alegre1
1IVI-RMA Valencia, Valencia, Spain.
Objective:
To describe novel embryo features capable of predicting implantation potential as input data for an artificial neural network (ANN) model.
Design:
Retrospective cohort study.
Setting:
University-affiliated private IVF center.
Patient(S):
This study included 637 patients from the oocyte donation program who underwent single-blastocyst transfer during two consecutive years.
Intervention(S):
None.
Main Outcome Measure(S):
The research was divided into two phases. Phase 1 consisted of the description and analysis of the following embryo features in implanted and nonimplanted embryos: distance and speed of pronuclear migration, blastocyst expanded diameter, inner cell mass area, and trophectoderm cell cycle length. Phase 2 consisted of the development of an ANN algorithm for implantation prediction. Results were obtained for four models fed with different input data. The predictive power was measured with the use of the area under the receiver operating characteristic curve (AUC).
Result(S):
Out of the five novel described parameters, blastocyst expanded diameter and trophectoderm cell cycle length had statistically different values in implanted and nonimplanted embryos. After the ANN models were trained and validated using fivefold cross-validation, they were capable of predicting implantation on testing data with AUCs of 0.64 for ANN1 (conventional morphokinetics), 0.73 for ANN2 (novel morphodynamics), 0.77 for ANN3 (conventional morphokinetics + novel morphodynamics), and 0.68 for ANN4 (discriminatory variables from statistical test).
Conclusion(S):
The novel proposed embryo features affect the implantation potential, and their combination with conventional morphokinetic parameters is effective as input data for a predictive model based on artificial intelligence.
More Related Videos
10:04A Neural Network-Based Identification of Developmentally Competent or Incompetent Mouse Fully-Grown Oocytes
Published on: March 3, 2018
05:13Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
Published on: June 21, 2024
