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Possible links between gut-microbiota and attention-deficit/hyperactivity disorders in children and adolescents

Nonglak Boonchooduang1, Orawan Louthrenoo1, Nipon Chattipakorn2,3

  • 1Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

European Journal of Nutrition
|September 12, 2020
PubMed

Insights

The gut microbiome may play a role in attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. This review explores differences in gut bacteria between those with and without ADHD.

Area of Science:

  • Neuroscience
  • Microbiology
  • Pediatrics

Background:

  • Gut-microbiota alterations are linked to neuropsychiatric conditions.
  • Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with unclear etiology.
  • The gut-brain axis suggests a connection between gut microbes and brain function in ADHD.

Purpose of the Study:

  • To review and summarize gut-microbiota diversity and taxonomic profiles in children and adolescents with ADHD.
  • To compare the gut microbiome of ADHD patients with that of non-ADHD individuals.
  • To propose future research directions for the gut microbiome in ADHD.

Main Methods:

  • Literature review of studies investigating the gut microbiome in ADHD.
  • Analysis of taxonomic profiles and diversity in children and adolescents.
  • Comparison of gut microbiota composition between ADHD and control groups.

Main Results:

  • Evidence suggests potentially distinctive gut-microbiota profiles in children and adolescents with ADHD compared to their peers.
  • The review consolidates current understanding of the gut-microbiota's association with ADHD.
  • Specific microbial patterns may be associated with ADHD, warranting further investigation.

Conclusions:

  • The gut microbiome is a potential factor in ADHD pathophysiology.
  • Further research is needed to elucidate the specific mechanisms of the gut-brain axis in ADHD.
  • Investigating the gut microbiome offers promising avenues for understanding and potentially treating ADHD.

Keywords:
ADHDDysbiosisGut–brain axisGut–microbiotaMicrobiome

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