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Review: Gastric cancer: Basic aspects.

Carlos Resende1, Carla Pereira Gomes1, Jose Carlos Machado1,2

  • 1i3S - Institute for Research and Innovation in Health and IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.

Helicobacter
|September 12, 2020
PubMed
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Immunotherapy shows promise for gastric cancer treatment by targeting its immune microenvironment. Research indicates patient stratification for immunotherapy will soon be a reality for gastric cancer.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Gastric cancer remains a leading cause of cancer-related deaths globally.
  • Advances in understanding gastric cancer have not translated into equally effective treatment strategies.

Purpose of the Study:

  • To review recent literature on the interplay between gastric cancer, its immune microenvironment, and immunotherapy response.
  • To explore the correlation between the immune microenvironment and gastric cancer's clinical behavior, including histologic and molecular subtypes.

Main Methods:

  • Literature review of studies published within the past year.
  • Analysis of data concerning gastric cancer's immune microenvironment and its influence on treatment outcomes.

Main Results:

  • The immune microenvironment significantly impacts gastric cancer's clinical behavior.
Keywords:
EBVgastric cancerimmunosurveillanceimmunotherapymicrosatellite instabilitytumor microenvironment

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  • Specific tumor subgroups, such as microsatellite- and EBV-positive tumors, show correlations with the immune microenvironment.
  • Evidence suggests patient stratification for immunotherapy in gastric cancer is emerging.

    • Conclusions:

    • The immune microenvironment is a critical factor in gastric cancer progression and treatment response.
    • Targeting the immune microenvironment holds potential for novel gastric cancer therapies.
    • Future research should focus on stratifying patients for immunotherapy based on immune biomarkers.