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Malignant Lesions Mimicking Endodontic Pathoses Lesion: A Systematic Review
Lauren Frenzel Schuch1, Carolina Clasen Vieira2, Ana Carolina Uchoa Vasconcelos2
1Department of Oral Diagnosis, Piracicaba Dental School, Universidade de Campinas, Piracicaba, São Paulo, Brazil.
Journal of Endodontics
|September 12, 2020
Summary
Malignant periapical lesions are rare but can be misdiagnosed. This review synthesizes clinical, radiologic, and histopathologic features of these conditions to improve diagnostic accuracy.
Area of Science:
- Oral Medicine
- Oral Pathology
- Oncology
Background:
- Malignant nonendodontic periapical lesions are infrequently diagnosed, leading to potential diagnostic errors in oral medicine.
- A comprehensive analysis of clinical, radiologic, and histopathologic features is needed for these rare conditions.
Purpose of the Study:
- To integrate and analyze published information on malignant lesions that mimic endodontic pathoses.
- To provide a comprehensive overview of their clinical, radiologic, and histopathologic characteristics.
Main Methods:
- A systematic online literature search was conducted in March 2020 across PubMed, Web of Science, and Scopus.
- Publications with sufficient clinical, radiologic, and histopathologic data for diagnosis confirmation were included.
- Data were assessed using a descriptive analysis approach.
Main Results:
- Sixty cases from 49 publications across 16 countries were analyzed.
- The mean age of affected individuals was 46.56 years, with nearly equal gender distribution.
- Lesions were most common in the posterior mandible, appearing radiographically as unilocular radiolucent areas. Metastasis and salivary gland malignant disease were the most prevalent histopathologic findings.
Conclusions:
- Several malignant periapical lesions can mimic endodontic pathoses.
- Due to the lack of distinct clinical or radiologic signs of malignancy, clinicians should consider these differential diagnoses routinely.
