RIFM fragrance ingredient safety assessment, 2-propanol, 1,1',1',1'-(1,2-ethanediyldinitrilo)tetrakis-, CAS Registry...

Area of Science:

• Chemical safety assessment
• Toxicology
• Environmental risk evaluation

Background:

• 2-Propanol, 1,1',1',1'-(1,2-ethanediyldinitrilo)tetrakis- is a chemical requiring safety evaluation for various endpoints.
• Previous data and read-across analog information are utilized to assess its safety profile.

Purpose of the Study:

• To evaluate the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety of 2-Propanol, 1,1',1',1'-(1,2-ethanediyldinitrilo)tetrakis-.
• To determine if the material is safe for its current declared levels of use.

Main Methods:

• Genotoxicity assessed using data from the target material and a read-across analog.
• Repeated dose and reproductive toxicity evaluated by calculating the margin of exposure (MOE).
• Phototoxicity/photoallergenicity assessed via UV spectra; local respiratory toxicity via threshold of toxicological concern (TTC); environmental safety via PBT assessment and risk quotients (PEC/PNEC).

Main Results:

• The material is not expected to be genotoxic.
• Calculated MOE >100 for repeated dose and reproductive toxicity indicates no safety concerns.
• No concerns for skin sensitization, phototoxicity/photoallergenicity, or local respiratory toxicity (exposure below TTC).
• The material is not persistent, bioaccumulative, and toxic (PBT), with environmental risk quotients <1.

Conclusions:

• The existing data support the safe use of 2-Propanol, 1,1',1',1'-(1,2-ethanediyldinitrilo)tetrakis- as described.
• No adverse effects are anticipated for genotoxicity, repeated dose toxicity, reproductive toxicity, skin sensitization, phototoxicity/photoallergenicity, or local respiratory toxicity.
• Environmental safety is confirmed, with no PBT properties and acceptable risk quotients.