High Performance Molecular Detection Biosensor Using Plasmonic Spiral Nanoantenna Based on Optical Fiber.

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Optoelectronics

Background:

• Development of highly sensitive biosensors is crucial for early disease detection and monitoring.
• Plasmonic nanostructures offer unique optical properties for enhanced sensing capabilities.
• Optical fiber-based sensors provide advantages in remote and real-time measurements.

Purpose of the Study:

• To propose and simulate a novel plasmonic nanospiral antenna biosensor.
• To optimize the dimensions of the nanospiral antenna for maximum refractive index sensitivity.
• To evaluate the sensor's performance in detecting various biomolecules.

Main Methods:

• Finite difference time domain (FDTD) method for electromagnetic simulation.
• Optimization of nanospiral antenna dimensions (inner-outer thicknesses, height).
• Surface plasmon resonance (SPR) principle for molecule detection.

Main Results:

• Optimized dimensions for the nanospiral antenna: 10 nm, 55 nm, and 40 nm.
• High refractive index sensitivity achieved, with a maximum of 3028 nm/RIU for cholesterol oxidase.
• Successful detection of Streptavidin, Urease, Uricase, Glucose oxidase, and Cholesterol oxidase.

Conclusions:

• The proposed plasmonic nanospiral antenna biosensor exhibits excellent sensitivity for biomolecule detection.
• The sensor design is adaptable for detecting a range of target molecules based on SPR.
• This technology holds promise for advanced biomedical diagnostics and sensing applications.