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Related Concept Videos

Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Related Experiment Video

Updated: Dec 9, 2025

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Tumor reversion and embryo morphogenetic factors.

Sara Proietti1, Alessandra Cucina2, Andrea Pensotti3

  • 1Department of Surgery "Pietro Valdoni", Sapienza University of Rome, 00161, Rome, Italy; Systems Biology Group Lab., Sapienza University of Rome, Rome, Italy.

Seminars in Cancer Biology
|September 13, 2020
PubMed
Summary
This summary is machine-generated.

Cancer cells can revert to a benign state by altering gene regulatory networks, bypassing genetic defects. Embryonic factors show potential for reprogramming tumor cells, offering new therapeutic avenues.

Keywords:
CytoskeletonEmbryonic extractsEpigenetic controlMorphogenetic fieldTCTPTumor reversionmicroRNA

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Area of Science:

  • Oncology
  • Developmental Biology
  • Epigenetics

Background:

  • Cancer cells exhibit malignant traits like migration and invasion.
  • Gene regulatory networks (GRNs) can be reprogrammed to alter cellular phenotype.
  • Tumor reversion suggests a switch in cellular functional configuration.

Purpose of the Study:

  • To explore the potential of inducing tumor reversion in cancer cells.
  • To investigate the role of morphogenetic factors and embryonic tissues in reversing cancer phenotypes.
  • To understand the mechanisms underlying cancer cell reprogramming.

Main Methods:

  • Analysis of studies on cancer cell phenotypic reversal.
  • Examination of reprogramming capabilities of oocytes and embryonic tissues.
  • Review of identified mechanisms including epigenetic modifications and pathway modulation.

Main Results:

  • Cancer cells can lose malignant characteristics, achieving tumor reversion.
  • Embryo-derived factors can revert malignant phenotypes of various tumors.
  • Reversion involves epigenetic changes, altered cell-microenvironment crosstalk, and modulated signaling pathways (TCTP-p53, PI3K-AKT, FGF, Wnt, TGF-β).

Conclusions:

  • Cancer cell reprogramming offers a novel therapeutic strategy.
  • Understanding these mechanisms can lead to new cancer treatment perspectives.
  • Preliminary clinical studies suggest therapeutic potential.