Eosinophilic granuloma of bone

This is a review of 48 patients registered in the University of British Columbia Bone Tumour Registry as having eosinophilic granuloma, with emphasis on the historical development, treatment and results. Comments on the place of scintigraphic imaging are included. Eosinophilic granuloma in its solitary form is a self-limiting disease requiring no treatment. It can, however, progress to multifocal disease or the historically important triad known as Hand-Schüller-Christian syndrome. There is some evidence that it may have an immunologic basis, but the authors have little new to offer with respect to its etiology.