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Updated: Dec 9, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
Multisystem effects of COVID-19: a concise review for practitioners
Gabrielle White-Dzuro1, Lauren E Gibson1, Luca Zazzeron1
1Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital , Boston, MA, USA.
Abstract:
While COVID-19 has primarily been characterized by the respiratory impact of viral pneumonia, it affects every organ system and carries a high consequent risk of death in critically ill patients. Higher sequential organ failure assessment (SOFA) scores have been associated with increased mortality in patients critically ill patients with COVID-19. It is important that clinicians managing critically ill COVID-19 patients be aware of the multisystem impact of the disease so that care can be focused on the prevention of end-organ injuries to potentially improve clinical outcomes. We review the multisystem complications of COVID-19 and associated treatment strategies to improve the care of critically ill COVID-19 patients.
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