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The Role of Stereotactic Biopsy in Brain Metastases
Kenny K H Yu1, Ankur R Patel1, Nelson S Moss1
1Department of Neurosurgery and Brain Metastasis Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York City, NY 10065, USA.
Abstract:
Brain metastases (BrM) affect up to 20% of patients with cancer and represent an increasing portion of patients with surgical brain tumors owing to improving prognoses of cancer patients in general and in many cases even of those with brain metastases. With advances in molecular biology and targeted therapy, the indications for neurosurgical sampling and specifically stereotactic biopsy are likely to change in the future. In this review the authors address some of the scientific advances in BrM biology, the clinical rationale and range of techniques currently used to perform stereotactic biopsy, and how the advent of molecular interrogation may potentially alter the way patients with BrM are managed in the future.
Insights
Brain metastases (BrM) impact many cancer patients, increasing the need for neurosurgical procedures like stereotactic biopsy. Future management may evolve with molecular advancements in BrM biology.
Area of Science:
- Neuro-oncology
- Cancer Biology
- Neurosurgery
Background:
- Brain metastases (BrM) affect up to 20% of cancer patients.
- BrM represent an increasing proportion of surgical brain tumors due to improved cancer prognoses.
- Advances in molecular biology and targeted therapies are influencing cancer patient outcomes.
Purpose of the Study:
- To review scientific advances in BrM biology.
- To discuss the clinical rationale and techniques for stereotactic biopsy.
- To explore the potential impact of molecular interrogation on BrM patient management.
Main Methods:
- Literature review of scientific advances in BrM biology.
- Analysis of current clinical rationale and techniques for stereotactic biopsy.
- Discussion on the implications of molecular interrogation in BrM management.
Main Results:
- BrM incidence is rising in surgical neuro-oncology cases.
- Stereotactic biopsy techniques are established but evolving.
- Molecular interrogation holds potential to personalize BrM treatment strategies.
Conclusions:
- The management of BrM is being reshaped by biological insights and technological advancements.
- Stereotactic biopsy remains a crucial diagnostic tool, with its indications potentially expanding.
- Future BrM care will likely integrate molecular profiling for tailored therapeutic approaches.
