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Anja Klussmeier1, Geoffrey A Behrens1, Vinzenz Lange1

  • 1DKMS Life Science Lab GmbH, St. Petersburger Straße 2, D-01069 Dresden, Deutschland.

Biospektrum : Zeitschrift Der Gesellschaft Fur Biologishe Chemie (GBCH) Und Der Vereinigung Fur Allgemeine Und Angewandte Mikrobiologie (VAAM)
|September 14, 2020
PubMed
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Rapidly identifying and isolating individuals infected with SARS-CoV-2 is key to controlling its spread. This study introduces a high-throughput PCR testing method using sample pooling to increase laboratory capacity and reduce costs during low prevalence periods.

Area of Science:

  • Molecular Biology
  • Virology
  • Epidemiology

Context:

  • Controlling the spread of SARS-CoV-2 requires efficient diagnostic testing.
  • Diagnostic laboratories face challenges in maintaining sufficient sample processing capacity.
  • Low population prevalence periods can strain resources for widespread testing.

Purpose:

  • To present a high-throughput, PCR-based approach for SARS-CoV-2 detection.
  • To evaluate the utility of sample pooling for improving testing efficiency.
  • To reduce costs and workload in diagnostic laboratories during SARS-CoV-2 surveillance.

Summary:

  • A high-throughput, PCR-based method for detecting SARS-CoV-2 is described.
  • Sample pooling is implemented to enhance laboratory capacity and reduce operational burden.

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  • This approach is particularly beneficial when population prevalence of SARS-CoV-2 is low.

    • Impact:

    • Increases the efficiency of SARS-CoV-2 diagnostic testing.
    • Reduces the cost and workload associated with PCR-based detection of SARS-CoV-2.
    • Supports public health efforts by enabling scalable surveillance and rapid response to outbreaks.