Related Experiment Video

Updated: Dec 9, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

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Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer

Hui-Chen Ku1, Ching-Feng Cheng1,2,3

  • 1Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan.

Frontiers in Endocrinology
|September 14, 2020
PubMed

Insights

Activating transcription factor 3 (ATF3) is a key stress-response protein. This review highlights ATF3's crucial roles in metabolism, immunity, and cancer, suggesting it as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Cellular Stress Response
  • Cancer Biology

Background:

  • Activating transcription factor 3 (ATF3) is a stress-induced transcription factor.
  • ATF3 integrates diverse extracellular signals, including ER stress, cytokines, and LPS.
  • It functions as a central hub in the cellular adaptive-response network.

Purpose of the Study:

  • To review the multifaceted roles of ATF3 in metabolism, immunity, and oncogenesis.
  • To explore ATF3's mechanisms as both a transcriptional activator and repressor.
  • To highlight ATF3's potential as a therapeutic target for metabolic disorders, immune diseases, and cancers.

Main Methods:

  • Literature review focusing on ATF3's regulatory functions.
  • Analysis of ATF3's involvement in glucose and adipose tissue metabolism.
  • Examination of ATF3's role in immune response and host defense.
  • Investigation of ATF3's impact on various cancer types (prostate, breast, colon, lung, liver).

Main Results:

  • ATF3 modulates glucose metabolism and adipose tissue regulation.
  • ATF3 is critical for immune regulation and maintaining host defense.
  • ATF3 plays significant roles in the oncogenesis of multiple cancers.
  • ATF3 regulates signaling pathways crucial for metabolism, immunity, and cancer.

Conclusions:

  • ATF3 acts as a master regulator of metabolic homeostasis.
  • ATF3 is implicated in immune disorders and the progression of various cancers.
  • Targeting ATF3 may offer therapeutic strategies for metabolic dyshomeostasis, immune disorders, and cancer treatment.
Keywords:
ATF3adipocytecancerglucose metabolismimmunity

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