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Related Experiment Video

Updated: Dec 9, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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MS, pregnancy and COVID-19.

Charmaine Yam1, Vilija Jokubaitis2, Kerstin Hellwig3

  • 1Department of Neurology, Royal Free Hospital NHS Trust, London, UK.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|September 14, 2020
PubMed
Summary

Pregnant women with multiple sclerosis (MS) face unique COVID-19 risks. This review offers guidance for neurologists on managing MS during pregnancy amid the pandemic.

Keywords:
COVID-19Multiple sclerosisSARS-COV-2antenatal carepregnancy

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Area of Science:

  • Neurology
  • Immunology
  • Obstetrics

Background:

  • Pregnant women with autoimmune diseases like multiple sclerosis (MS) have heightened concerns about SARS-CoV-2 infection and COVID-19.
  • Limited data exists to guide clinical management and advice for this specific population.
  • Existing COVID-19 and pregnancy data often originates from obstetrics, potentially unfamiliar to neurologists.

Purpose of the Study:

  • To provide a framework for neurologists to guide pregnant women with MS and those considering pregnancy.
  • To address the impact of COVID-19 on pregnant women with MS, their babies, and antenatal care.
  • To synthesize evidence from previous coronavirus infections and the current pandemic.

Main Methods:

  • Literature review synthesizing available data on COVID-19, pregnancy, and multiple sclerosis.
  • Analysis of impacts on maternal health, fetal outcomes, and healthcare provision.
  • Integration of evidence from prior coronavirus outbreaks and the ongoing pandemic.

Main Results:

  • Discussion of the specific risks of COVID-19 for pregnant women with MS.
  • Assessment of potential impacts on fetal development and neonatal outcomes.
  • Examination of how the pandemic affects routine antenatal care and MS management.

Conclusions:

  • Neurologists require specific guidance for advising pregnant patients with MS during the COVID-19 pandemic.
  • Individualized advice is crucial, considering maternal, fetal, and disease-specific factors.
  • This review offers a structured approach to managing MS in pregnant individuals amidst the pandemic.