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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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Related Experiment Video

Updated: Jun 23, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study.

Ioanna Zimianiti1,2, Sheena Waters1, Adil Harroud3,4,5

  • 1Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK.

Annals of Clinical and Translational Neurology
|June 22, 2026
PubMed
Summary

The genetic variant rs10191329A is linked to worse cognitive function in healthy individuals. This finding suggests a potential role for this variant in neurological disease outcomes, including Multiple Sclerosis.

Keywords:
cognitive functiongeneticsmultiple sclerosis

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Published on: June 21, 2018

Related Experiment Videos

Last Updated: Jun 23, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Neurogenetics
  • Cognitive Neuroscience

Background:

  • A genome-wide association study identified the genetic variant rs10191329A associated with Multiple Sclerosis severity and long-term disability.
  • Brain resilience was implicated as a key factor influencing outcomes in Multiple Sclerosis.

Purpose of the Study:

  • To investigate the potential influence of the rs10191329A genetic variant on cognitive function.
  • To explore the association of rs10191329A with cognition in healthy controls and patients with neurological diseases.

Main Methods:

  • Utilized the UK Biobank dataset for the study.
  • Assessed cognitive performance using tests for reaction time, fluid intelligence, and prospective memory.

Main Results:

  • Observed a weak but consistent association between the rs10191329A variant and poorer cognitive function in healthy controls.
  • Identified similar, albeit non-significant, trends of impaired cognition associated with rs10191329A in Multiple Sclerosis, Parkinson's disease, and dementia cohorts.

Conclusions:

  • The findings support the hypothesis that the rs10191329A genetic variant may impact cognitive function.
  • Results suggest rs10191329A could influence neurological disease outcomes, potentially through effects on brain health and resilience.