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The Descemet Membrane in Primary Congenital Glaucoma
Shikha Gupta1, Abadh K Chaurasia1, Seema Sen2
1Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Cornea
|September 14, 2020
Summary
Primary congenital glaucoma (PCG) eyes show thickened Descemet membrane (DM) and pre-Descemet layer (PDL) compared to healthy eyes. This thickening extends to the anterior chamber angle, impacting glaucoma progression.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Corneal Imaging
Background:
- Primary congenital glaucoma (PCG) is a severe form of glaucoma.
- Understanding Descemet membrane (DM) and pre-Descemet layer (PDL) changes is crucial for PCG management.
Purpose of the Study:
- To evaluate Descemet membrane (DM) morphology in primary congenital glaucoma (PCG) using high-definition anterior segment optical coherence tomography (ASOCT) and histopathology.
- To compare DM thickness in PCG eyes with fellow eyes and healthy controls.
Main Methods:
- ASOCT imaging of DM and anterior chamber angle in 22 PCG eyes.
- Comparison of DM thickness with 8 fellow eyes and 12 healthy controls.
- Histopathological analysis of corneal tissues from 9 PCG eyes and 6 control eyes.
Main Results:
- ASOCT revealed thickened DM complex or a hyper-reflective double layer in all PCG eyes.
- Significant DM thickening (32.0 ± 11.2 μm) in PCG eyes versus controls (11.5 ± 1 μm) (P < 0.001).
- Histopathology confirmed DM and PDL thickening in PCG eyes compared to controls.
Conclusions:
- Eyes with PCG exhibit thickened DM and PDL.
- This thickening extends peripherally to the angle recess, potentially contributing to PCG pathogenesis.
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