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Updated: Jun 6, 2026
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
Anterior segment optical coherence tomography-guided assessment of wound healing after cyanoacrylate glue patch for
Manpreet Kaur1, Vaibhav Namdev1, Silpa Lalu1
1Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Purpose:
To evaluate wound healing after cyanoacrylate glue patch (CGP) application in corneal perforations using anterior segment optical coherence tomography (ASOCT).
Design:
Prospective interventional case series.
Methods:
Twenty-eight patients with corneal perforations (<4 mm) underwent CGP application. The primary outcome measure was wound healing pattern on ASOCT after CGP application. Secondary outcomes were time to removal of CGP and anatomical success. Follow-up was performed on POD 1 and every 2 weeks till CGP removal.
Results:
Three distinct wound healing patterns were observed on ASOCT: Type 1 with corrugated hyper-reflective mass corresponding to CGP with underlying shadowing, Type 2 pattern with ongoing stromal regeneration without continuity with surrounding healthy cornea, and Type 3 with complete stromal regeneration beneath the CGP continuous with surrounding cornea. On POD 1, 100% cases had type 1 pattern. At 2 weeks, 85.7% had type 2; 14.3% had type 1 pattern. At 4 weeks, 35.7% cases had type 3 and 64.3% had type 2 pattern. Five cases underwent early glue removal (type 2 pattern) at 31.8 ± 2.5 days because of CGP intolerance; of these, 40% (2/5) developed a leak and required reapplication of CGP. Total 82.1% cases achieved type 3 pattern by 8 weeks. CGP was removed after documentation of type 3 pattern in 82.1% cases at 41.7 ± 9.2 days; no case developed wound leak.
Conclusions:
ASOCT is a useful adjunct to objectively monitor wound healing after CGP and guide regarding optimal timing for its removal, with type 3 pattern correlating with higher anatomical success.
