Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature
Stéphane Derruau1,2,3, Julien Robinet1, Valérie Untereiner4
1Département de Biologie Orale, UFR Odontologie, Université de Reims Champagne-Ardenne, 2 rue du Général Koenig, 51100 Reims, France.
Molecules (Basel, Switzerland)
|September 15, 2020
Summary
Vibrational spectroscopy of saliva shows high diagnostic potential for various diseases, including cancers and diabetes. This rapid, non-invasive technique offers a promising new tool for disease biomarker discovery and early detection.
Area of Science:
- Biomedical Diagnostics
- Spectroscopy
- Salivary Biomarkers
Background:
- Saliva serves as a health indicator, reflecting the body's status.
- Vibrational spectroscopy (Raman and infrared) offers detailed salivary fingerprints for disease biomarker discovery.
Purpose of the Study:
- To systematically review the diagnostic potential of vibrational spectroscopy for oral and general diseases using saliva.
- To evaluate diagnostic performance metrics like sensitivity, specificity, and accuracy.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Searches conducted in MEDLINE-PubMed and Scopus databases (May 2020).
- Inclusion of 18 publications over a 10-year period.
Main Results:
- 18 publications covered 10 diseases (3 oral, 7 general), demonstrating high diagnostic performance.
- Thirteen articles focused on six cancer types (mouth, nasopharynx, lung, esophagus, stomach, breast).
- Other diseases included periodontitis, Sjögren's syndrome, diabetes, and myocardial infarction. Raman spectroscopy, particularly surface-enhanced Raman spectroscopy, was predominantly used.
Conclusions:
- Vibrational spectroscopy is a promising rapid, label-free, and non-invasive salivary biometric tool for disease diagnosis.
- The technique shows potential for investigating subclinical diseases, warranting further developmental studies.
Related Concept Videos
01:19MALDI-TOF Mass Spectrometry
6.2K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
6.2K
01:26Assessment of the Mouth
819
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
819
01:30Serum Laboratory Studies, Stool Test, Breath Test
608
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
608
01:23Salivary Glands and Saliva
1.8K
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
1.8K
01:33Peptide Identification Using Tandem Mass Spectrometry
7.8K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
7.8K