Discrimination of copper and silver ions based on the label-free quantum dots

A simple and fast method for copper ions (Cu²⁺) and silver ions (Ag⁺) detection was established with cadmium telluride quantum dots (CdTe QDs) as fluorescent probes. In the presence of Cu²⁺ or Ag⁺, the fluorescence intensity of TGA-CdTe QD can be significantly quenched, which fitted a linear relationship between the fluorescence quenching degree (F₀-F)/F₀ and the concentration of metal ions. In this work, the lowest detected concentration for Cu²⁺ and Ag⁺ was 35.0 nM and 25.3 nM, respectively. In addition, the differentiation of Cu²⁺ and Ag⁺ at different concentrations was realized with the principal component analysis (PCA). Furthermore, Cu²⁺ was successfully detected in body fluids. This method provides a good potential for copper ions and silver ions detection with simplicity, rapidity, and excellent selectivity.