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Acetate- vs lactate-buffered crystalloid solutions: Protocol for a systematic review with meta-analysis and trial
Karen Louise Ellekjaer1, Anders Perner1, Praleene Sivapalan1
1Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Acta Anaesthesiologica Scandinavica
|September 15, 2020
Summary
This systematic review compares acetate- vs lactate-buffered crystalloid solutions for fluid resuscitation. It aims to clarify which buffered solution offers better patient outcomes in hospitalized individuals.
Area of Science:
- Critical Care Medicine
- Fluid Resuscitation
- Clinical Trials
Background:
- Buffered crystalloid solutions are common first-line resuscitation fluids.
- Current guidelines lack differentiation between buffered solution types.
- Acetate- and lactate-buffered solutions represent key types.
Purpose of the Study:
- To systematically review and assess patient-important outcomes.
- Comparison between acetate-buffered and lactate-buffered crystalloid solutions.
- Focus on hospitalized patients receiving intravenous fluids.
Main Methods:
- Systematic review of randomized clinical trials (RCTs).
- Meta-analysis and trial sequential analysis will be employed.
- Searches in major databases (Cochrane, MEDLINE, EMBASE, Epistemonikos).
- Adherence to PRISMA guidelines and GRADE assessment for evidence quality.
Main Results:
- Data synthesis on patient-important outcomes.
- Assessment of effects of acetate- vs lactate-buffered crystalloids.
- Evaluation of risk of bias and random errors.
Conclusions:
- The review will provide crucial data on buffered crystalloid solutions.
- Understanding the impact on patient outcomes is key.
- Informs clinical practice regarding fluid selection in hospitalized patients.
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