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RAGE and its ligands: from pathogenesis to therapeutics

Nitish Jangde1,2, Rashmi Ray1, Vivek Rai1

  • 1Laboratory of Vascular Immunology, Institute of Life Sciences, Bhubaneswar, India.

Critical Reviews in Biochemistry and Molecular Biology
|September 16, 2020
PubMed

Insights

The Receptor for Advanced Glycation End Products (RAGE) is a cell surface receptor involved in inflammation and other diseases. Targeting RAGE signaling pathways offers a promising therapeutic strategy for various RAGE-mediated pathologies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathophysiology

Background:

  • Receptor for Advanced Glycation End Products (RAGE) is an immunoglobulin-like cell surface receptor.
  • RAGE functions as a pattern recognition receptor (PRR), binding diverse ligands and initiating signaling cascades.
  • RAGE is implicated in numerous diseases, including inflammation, cancer, diabetes, and neurodegenerative disorders.

Purpose of the Study:

  • To review the physical and physiological aspects of RAGE biology in mammals.
  • To highlight the importance of targeting RAGE signaling in treating RAGE-mediated pathologies.

Main Methods:

  • Literature review of RAGE biology and its role in disease.
  • Analysis of RAGE signaling pathways and therapeutic targeting strategies.

Main Results:

  • RAGE ligation triggers distinct signaling cascades and transcription factor activation.
  • RAGE is involved in a wide array of pathophysiological conditions.
  • Targeting RAGE signaling via inhibitors and antibodies shows therapeutic potential.

Conclusions:

  • RAGE is a key player in various disease processes.
  • Inhibitors and anti-RAGE antibodies represent a promising therapeutic avenue for RAGE-mediated diseases.
Keywords:
Receptorinflammationinflammatory diseasesligandssignaling

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