RAGE and its ligands: from pathogenesis to therapeutics
Nitish Jangde1,2, Rashmi Ray1, Vivek Rai1
1Laboratory of Vascular Immunology, Institute of Life Sciences, Bhubaneswar, India.
Critical Reviews in Biochemistry and Molecular Biology
|September 16, 2020
Summary
The Receptor for Advanced Glycation End Products (RAGE) is a cell surface receptor involved in inflammation and other diseases. Targeting RAGE signaling pathways offers a promising therapeutic strategy for various RAGE-mediated pathologies.
Area of Science:
- Immunology
- Molecular Biology
- Pathophysiology
Background:
- Receptor for Advanced Glycation End Products (RAGE) is an immunoglobulin-like cell surface receptor.
- RAGE functions as a pattern recognition receptor (PRR), binding diverse ligands and initiating signaling cascades.
- RAGE is implicated in numerous diseases, including inflammation, cancer, diabetes, and neurodegenerative disorders.
Purpose of the Study:
- To review the physical and physiological aspects of RAGE biology in mammals.
- To highlight the importance of targeting RAGE signaling in treating RAGE-mediated pathologies.
Main Methods:
- Literature review of RAGE biology and its role in disease.
- Analysis of RAGE signaling pathways and therapeutic targeting strategies.
Main Results:
- RAGE ligation triggers distinct signaling cascades and transcription factor activation.
- RAGE is involved in a wide array of pathophysiological conditions.
- Targeting RAGE signaling via inhibitors and antibodies shows therapeutic potential.
Conclusions:
- RAGE is a key player in various disease processes.
- Inhibitors and anti-RAGE antibodies represent a promising therapeutic avenue for RAGE-mediated diseases.
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