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SMYD3 promotes colon adenocarcinoma (COAD) progression by mediating cell proliferation and apoptosis

Fu-Ren Yue1, Zhi-Bin Wei1, Rui-Zhen Yan1

  • 1Department of Clinical Laboratory, Tianjin Baodi Hospital, Tianjin 301800, P.R. China.

Experimental and Therapeutic Medicine
|September 16, 2020
PubMed

Insights

SET and MYND domain-containing protein 3 (SMYD3) is upregulated in colon adenocarcinoma (COAD), promoting tumor growth and affecting cell cycle. This suggests SMYD3 is a potential therapeutic target for COAD treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Colon adenocarcinoma (COAD) is a prevalent malignancy requiring novel therapeutic targets.
  • SET and MYND domain-containing protein 3 (SMYD3), a methyltransferase, has known roles in cancer progression, but its function in COAD is unexplored.

Purpose of the Study:

  • To investigate the role and potential of SMYD3 as a molecular target in colon adenocarcinoma.

Main Methods:

  • Analysis of The Cancer Genome Atlas (TCGA) database and immunohistochemical assays for SMYD3 expression in COAD tissues.
  • In vitro assays (colony formation, MTT, FCM) and in vivo animal models to assess SMYD3's functional impact on COAD cells and tumor growth.

Main Results:

  • SMYD3 expression is significantly upregulated in human COAD tissues.
  • Elevated SMYD3 levels correlate with poorer prognosis and advanced tumor stage in COAD patients.
  • SMYD3 influences COAD cell proliferation, apoptosis, and cell cycle, and promotes tumor growth in vivo.

Conclusions:

  • SMYD3 plays a crucial role in the progression of colon adenocarcinoma.
  • SMYD3 represents a promising novel molecular target for the development of targeted therapies against COAD.
Keywords:
SET and MYND domain-containing proteinSMYD3apoptosiscolon adenocarcinomamolecular targetproliferation

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