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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
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Treatment approaches in relapsed or refractory peripheral T-cell lymphomas
Cheryl Foster1,2, John Kuruvilla1,2
1Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 6-424 700 University Avenue, Toronto, ON, M5G 1Z5, Canada.
F1000Research
|September 16, 2020
Summary
Peripheral T-cell lymphomas (PTCLs) are aggressive blood cancers with limited treatment options. Newer targeted therapies show promise for relapsed or refractory PTCL, improving patient outcomes.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Peripheral T-cell lymphomas (PTCLs) are rare, aggressive non-Hodgkin's lymphomas with historically poor prognoses.
- Current treatment strategies often fail, leading to disease progression and a high unmet need in relapsed or refractory cases.
Purpose of the Study:
- To review the current treatment landscape for relapsed and refractory PTCL.
- To explore emerging targeted agents and immunotherapies for PTCL.
Main Methods:
- Literature review of clinical trials and treatment strategies for PTCL.
- Analysis of newer targeted agents and their efficacy in relapsed/refractory settings.
Main Results:
- Brentuximab vedotin demonstrates success in pretreated PTCL, supporting earlier use.
- New targeted agents are being developed for relapsed PTCL, offering improved outcomes.
Conclusions:
- Targeted agents and immunotherapy represent significant advances in PTCL treatment.
- Innovative clinical trial designs are essential for evaluating new therapies in this heterogeneous disease.
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