Hantzsch Ester-Mediated Synthesis of Phenanthridines under Visible-Light Irradiation
Savita B Nagode1,2, Ruchir Kant3, Namrata Rastogi1,2
1Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sec. 10, JankipuramExtension, Sitapur Road, P.O. Box 173, Lucknow, 226031, India.
Abstract:
An efficient photocatalytic synthesis of phenanthridines mediated by an organo-photoredox initiator Hantzsch ester has been developed via denitrogenative intramolecular annulation of benzotriazolyl chalcones. The highly reducing photoactivated Hantzsch ester facilitates the transformation of benzotriazolyl chalcones into phenanthridinyl chalcones through photoinduced electron transfer (PET) and hydrogen atom transfer (HAT) processes. The mild reaction conditions utilizing inexpensive Hantzsch ester as photosensitizer, wide reaction scope and excellent functional group tolerance are notable attributes of the methodology.
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