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Melatonin attenuates chemical-induced cardiotoxicity.
S Zare1, F S Heydari1, A W Hayes2
1Department of Pharmacodynamics and Toxicology, School of Pharmacy, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Human & Experimental Toxicology
|September 16, 2020
Summary
Melatonin may protect against cardiotoxicity induced by environmental chemicals and drugs. This review explores melatonin
Area of Science:
- Environmental toxicology
- Cardiovascular pharmacology
- Biochemistry
Background:
- Cardiotoxicity from environmental chemicals and drugs is a significant health concern.
- Free radicals and reactive oxygen species are key contributors to cardiac tissue injury.
- There is a critical need for effective strategies to prevent and treat chemical-induced cardiotoxicity.
Purpose of the Study:
- To review the therapeutic potential of melatonin in mitigating cardiotoxicity.
- To explore the molecular mechanisms underlying melatonin's protective effects against cardiotoxic agents.
- To highlight the role of melatonin in cardiovascular health and disease.
Main Methods:
- Literature review of studies investigating melatonin's effects on cardiotoxicity.
- Analysis of research on melatonin's antioxidant and free radical scavenging properties.
- Examination of evidence from various model systems regarding melatonin's cardiovascular benefits.
Main Results:
- Melatonin demonstrates significant protective effects against various forms of cardiotoxicity.
- Identified mechanisms include free radical scavenging and antioxidant activity.
- Endogenous melatonin plays a role in cardiovascular health, and supplementation shows promise in cardiac disorders.
Conclusions:
- Melatonin is a promising therapeutic agent for treating cardiotoxicity induced by environmental chemicals and drugs.
- Further research into melatonin's mechanisms could lead to novel treatment strategies for cardiovascular toxicity.
- Melatonin's established safety profile supports its consideration for cardiovascular protection.
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