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Crosstalk between coronavirus disease 2019 and cardiovascular disease and its treatment

Qing Ye1, Dezhao Lu2, Shiqiang Shang1

  • 1National Clinical Research Center for Child Health, National Children's Regional Medical Center, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.

ESC Heart Failure
|September 16, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) significantly impacts cardiovascular disease (CVD). This review analyzes how COVID-19 affects CVD, increasing mortality risk and causing new cardiovascular complications.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiovascular disease (CVD) patients are frequently diagnosed with coronavirus disease 2019 (COVID-19).
  • The intricate relationship between COVID-19 and CVD remains incompletely understood.
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection poses significant risks to cardiovascular health.

Purpose of the Study:

  • To systematically review and analyze the existing evidence on the interaction between COVID-19 and CVD.
  • To understand the mechanisms by which SARS-CoV-2 impacts the cardiovascular system.
  • To evaluate the influence of COVID-19 on CVD development and patient outcomes.

Main Methods:

  • Systematic review of available literature.
  • Searches conducted in electronic databases MEDLINE and EMBASE.
  • Analysis of scientific evidence on COVID-19 and cardiovascular complications.

Main Results:

  • SARS-CoV-2 infection can precipitate CVD through cytokine storms, oxygen imbalance, and renin-angiotensin-aldosterone system disruption.
  • COVID-19 can exacerbate pre-existing CVD or lead to new-onset cardiovascular issues like acute myocardial injury, arrhythmia, and heart failure.
  • Pre-existing CVD is a critical factor associated with increased mortality risk in COVID-19 patients.

Conclusions:

  • There is a clear and significant interaction between COVID-19 and cardiovascular disease.
  • COVID-19 infection poses a substantial threat to individuals with underlying CVD and can induce new cardiovascular conditions.
  • Close monitoring for cardiovascular complications is essential for managing COVID-19 patients and reducing mortality.

Keywords:
COVID-19Cardiovascular diseaseRenin-angiotensin-aldosterone systemSARS-CoV-2

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