Related Experiment Video
Updated: Dec 8, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Progressive ataxia and cognitive decline in a 67-year-old male: a diagnostic challenge
Dina Osman1, Alice Weidner2, Mayuri Madhra2
1General Internal Medicine, Cumberland Infirmary of Carlisle, Newtown Road, Carlisle, CA2 7HY, UK,
Abstract:
We report the case of a 67-year-old male who presented with a six-week history of progressive unsteadiness, cognitive impairment and weight loss, in the context of a recent bereavement. Magnetic resonance imaging (MRI) performed several weeks earlier excluded acute stroke. Examination revealed gross bilateral ataxia, bradyphrenia and physical manifestations of depression. Collateral history suggested rapidly progressing symptoms over three months. Repeat MRI head showed features suggestive of Creutzfeldt-Jakob disease (CJD) including T2 hyperintensities in the basal ganglia. Cerebrospinal ˜fluid (CSF) samples were positive for 14-3-3 protein, S100b and real-time quaking-induced conversion (RT-QuIC) proteins confirming the diagnosis of sporadic CJD (sCJD).
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Cognitive Development During Adulthood
Dementia
The progression of dementia is generally gradual....
Alzheimer's Disease: Treatment
Parkinson's Disease: Overview
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

