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Updated: Dec 8, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
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Traceless Bidentate Directing Group Assisted Cobalt-Catalyzed sp2-C-H Activation and [4 + 2]-Annulation Reaction with
Arnab Dey1, Chandra M R Volla1
1Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Abstract:
An efficient cobalt-catalyzed [4 + 2] annulation of hydrazones and 1,3-diynes has been developed for the synthesis of 3-alkynylated isoquinolines engaging 2-aminopyridine as a traceless bidentate directing group. The strategy has been successfully extended for the synthesis of 3,3'-biisoquinoline moieties via both one-pot as well as sequential approaches. The utilization of a traceless bidentate directing group with an inexpensive and earth-abundant cobalt-catalyst under operationally simple reaction conditions makes the present transformation more valuable and appealing.
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