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Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells
Maike Effern1, Michael Hölzel1
1Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
Immunity
|September 16, 2020
Abstract:
In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8+ T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.
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