Recent Advances in Affinity MOF-Based Sorbents with Sample Preparation Purposes

Area of Science:

• Materials Science
• Analytical Chemistry
• Biochemistry

Background:

• Sample preparation is crucial for accurate analysis of complex matrices.
• Traditional methods often lack selectivity and efficiency.
• Metal-organic frameworks (MOFs) offer tunable properties for material design.

Purpose of the Study:

• To review recent advances in biomolecule-modified MOFs for affinity sorbents.
• To describe preparation and incorporation strategies for these advanced materials.
• To highlight applications in selective extraction and sample cleanup.

Main Methods:

• Literature review of MOF modification with biomolecules (amino acids, proteins, etc.).
• Analysis of synthesis and integration techniques for MOF-based biocomposites.
• Evaluation of sorbent performance in selective molecule extraction from complex samples.

Main Results:

• Successful modification of MOFs with diverse biomolecules yields effective affinity sorbents.
• Various preparation strategies enable tailored material properties for specific applications.
• Biocomposite sorbents demonstrate high selectivity and efficiency in complex sample cleanup.

Conclusions:

• Biomolecule-modified MOFs represent a promising class of affinity materials for advanced sample preparation.
• These materials offer significant potential for selective extraction and purification in analytical chemistry.
• Further research into MOF-biomolecule interactions can unlock new applications.