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Updated: Dec 8, 2025

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
Ru(II)-Catalyzed Tunable Cascade Reaction via C-H/C-C Bond Cleavage
Zi Yang1, Qi Yue1, Mengqi Yang1
1Department Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. China.
Abstract:
A facile synthesis of various 3-(alkoxyalkyl)-1H-indoles from pyrazolidinones, 2-acetylenic ketones, and alkyl alcohols via C-H/C-C bond activation has been developed. The reaction proceeds smoothly under the proper reaction conditions, and preliminary mechanistic studies suggest that NaOAc is crucial for C-C bond activation. The advantages of the present method represent a redox-neutral process and exhibit excellent chemo and regioselectivity.
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